Function of a truncated glucocorticoid receptor form at a negative glucocorticoid response element in the proopiomelanocortin gene
نویسندگان
چکیده
منابع مشابه
Composite glucocorticoid regulation at a functionally defined negative glucocorticoid response element of the human corticotropin-releasing hormone gene.
Glucocorticoid-dependent negative feedback of the hypothalamic-pituitary-adrenal axis is mediated in part through direct inhibition of hypothalamic CRH gene transcription. In the present study, we sought to further localize and characterize glucocorticoid receptor (GR) and AP-1 interactions at a functionally defined negative glucocorticoid response element (nGRE) of the CRH promoter. Transient ...
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Glucocorticoids play important roles in lung development and function by modulating the expression of a variety of genes. The type 1 vasoactive intestinal polypeptide (VIP) receptor gene is highly expressed in the lung where it mediates VIP physiological functions. In this study, the effect of glucocorticoid on VIP receptor gene expression was examined. Dexamethasone (100 n) suppresses endogeno...
متن کاملIdentification of Glucocorticoid Response Element of the Rat TRH gene
OBJECTIVES It was suggested that glucocorticoid exerts cell-specific effects on thyrotropin-releasing hormone (TRH) gene expression at the transcriptional level. Although there is no typical palindromic glucocorticoid response element (GRE) on the rat TRH gene promoter, a perfect GRE half-site is found between -205 bp and -211 bp. We investigated whether the segment between -242 bp and -200 bp ...
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Purified glucocorticoid receptor (GR) from rat liver was used for a quantitative analysis of the protein-DNA interaction at specific GR-binding segments within the 5'-long terminal repeat of the mouse mammary tumor virus. A truncated receptor was generated and used to demonstrate formation of heterodimeric GR, which furthermore was shown to be in rapid equilibrium with receptor-monomer. The rel...
متن کاملGlucocorticoid inhibition of transcription from episomal proopiomelanocortin gene promoter.
Glucocorticoid hormones alter transcription of specific genes. Glucocorticoid-stimulated genes have been especially useful in unraveling molecular events responsible for positive gene regulation in mammals. The gene encoding proopiomelanocortin (POMC), which is under feedback inhibition by glucocorticoids, provides a model system to study negative gene regulation. Using an episomal bovine papil...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2001
ISSN: 0952-5041,1479-6813
DOI: 10.1677/jme.0.0260043